Mucosal Adjuvanticity of a Shigella Invasin Complex with DNA-Based Vaccines
نویسندگان
چکیده
منابع مشابه
Mucosal adjuvant properties of the Shigella invasin complex.
The Shigella invasin complex (Invaplex) is an effective mucosal vaccine capable of protecting against Shigella challenge in animal models. The major antigenic constituents of Invaplex are the Ipa proteins and lipopolysaccharide. The cell-binding capacity of the Ipa proteins prompted the investigation into the adjuvanticity of Invaplex. Using ovalbumin (OVA) as a model antigen, intranasal immuni...
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Several live attenuated Shigella vaccines of different serotypes have been shown to be safe, immunogenic, and in one case effective against challenge with virulent strains. The ability to invade epithelial cells remains critical for the success of these vaccine candidates. Live, orally administered Shigella vaccine derivatives are also being evaluated as multivalent mucosal vaccines able to del...
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ژورنال
عنوان ژورنال: Clinical and Vaccine Immunology
سال: 2009
ISSN: 1556-6811,1556-679X
DOI: 10.1128/cvi.00435-08